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Immune cells could lead to a new cancer vaccine

A new study by yale university discovered critical mechanisms for immune system cells to congregate and communicate with one another in order to detect and kill tumours. The Researchers have been published in the Cell journal. These discoveries could open the road for new cancer vaccinations that could improve survival rates in several forms of cancers. In recent years, researchers have discovered that patients with lung cancer who are most likely survive to develop lymph node-like formations around tumours. These structures, like lymph nodes, produce a variety of immune system cells, including CD4 helper T cells, which detect tumours, B cells, which make anti-cancer antibodies, and CD8 killer T cells, which destroy cancer cells.

“The field has been attempting to figure out how these mini-immune systems are established up in the cancer micro-environment and why they correlate with wonderful outcomes,” said Nikhil Joshi, assistant professor of immunobiology and co-senior author of the study. These immune system cells were discovered to communicate with one another.

A team led by Joshi, Can Cui, a Yale School of Medicine Ph.D. student and physician, and Joseph Craft, the Paul B. Beeson Professor of Medicine (rheumatology) and professor of immunobiology, analyzed cancer survivors’ tumour genetics and then developed mouse models with genetic characteristics similar to those survivors.

Their research discovered that B cells do more than just produce anti-cancer antibodies. In order for CD8 killer T cells to mount a robust response, B cells must first engage with CD4 helper T cells to select tumours to attack.

Before tumours can be targeted, T cells and B cells must communicate with one another. Several cancer vaccines were already in the works to stimulate the generation of T cells that had colonized the areas around cancers such as melanoma and glioblastomas, as well as lung cancer. In reality, BioNTech and Moderna were founded in part to produce cancer vaccines during the COVID-19 pandemic and helped develop vaccinations to help the human body identify and fight the virus.



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